Italy is at the forefront of shaping the European HPC-QC ecosystem, playing a key role in two major initiatives: EuroQHPC-I and QEC4QEA. As one of the selected hosting entities for a European quantum computer, Italy is set to pioneer the integration of quantum computing with high-performance computing (HPC). This integration, conducted alongside other selected hosting entities, will mark a significant step toward the hybrid computing architectures of the future. Simultaneously, Italy has been chosen to lead Europe’s first Center of Excellence in Quantum Computing, QEC4QEA. This initiative will drive the development of the first HPC-QC applications, accelerating the adoption of quantum technologies in scientific and industrial domains. By spearheading both infrastructure deployment and software innovation, Italy is in pole position to build the future European HPC-QC ecosystem, reinforcing its leadership in quantum and high-performance computing.