The Hochschild cohomology of a differential graded algebra or more generally of a differential graded category admits a natural map to the graded center of its derived category: the characteristic homomorphism. We interpret this map as an edge homomorphism in a spectral sequence, which allows to study the characteristic homomorphism systematically in many interesting examples from algebra, geometry, topology and physics. To illustrate this, we will discuss several concrete examples related to coherent sheaves on algebraic curves and cochains of classifying spaces of Lie groups. If time permits, I will also indicate a new extension of this framework to $A_\infty$-categories. Some of this is joint work with M. Szymik (Sheffield) other with A. Phimister (Leicester).